{"id":2205,"date":"2019-06-13T10:57:30","date_gmt":"2019-06-13T02:57:30","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2205"},"modified":"2023-03-02T14:03:57","modified_gmt":"2023-03-02T06:03:57","slug":"hmb-and-protein-metabolism","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2205","title":{"rendered":"HMB\u4e0e\u86cb\u767d\u8d28\u4ee3\u8c22"},"content":{"rendered":"
\u6885\u91cc\u57c3\u68c0\u6d4b<\/a>, <\/span>\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66<\/a>, <\/span>\u86cb\u767d\u8d28\u4ee3\u8c22<\/a><\/div>\n\n

\u524d\u8a00<\/span><\/strong><\/span><\/p>\n

\n

\u968f\u7740\u5bf9\u9aa8\u9abc\u808c\/\u7626\u4f53\u91cd(Lean Body Mass)\u4e0e\u5065\u5eb7\u4e4b\u95f4\u5173\u8054\u7684\u77e5\u8bc6\u666e\u53ca\uff0c\u6709\u5173\u201c\u589e\u808c\u201d\u8fd9\u4e00\u6982\u5ff5\u7684\u9002\u7528\u4eba\u7fa4\u9010\u6e10\u4ece\u5355\u4e00\u7684\u523b\u677f\u5370\u8c61\uff08\u8fd0\u52a8\u53ca\u5065\u8eab\u884c\u4e1a\uff09\u5f80\u6db5\u76d6\u8303\u56f4\u66f4\u5e7f\u7684\u4eba\u7fa4\u4e2d\u6e17\u900f\u3002\u65e0\u8bba\u76ee\u6807\u4eba\u7fa4\u662f\u60f3\u63d0\u9ad8\u8fd0\u52a8\u6210\u7ee9\u7684\u8fd0\u52a8\u5458\uff0c\u6216\u662f\u9700\u8981\u9632\u6b62\u808c\u8089\u6d41\u5931\u7684\u75c5\u4eba\uff0c\u8fd8\u662f\u6709\u7740\u5065\u5eb7\u8870\u8001\u8bc9\u6c42\u7684\u8001\u9f84\u4eba\u53e3\uff0c \u5982\u4f55\u4fdd\u5b58\u7626\u4f53\u91cd\u53ca\u4fc3\u8fdb\u808c\u8089\u751f\u957f\u5df2\u6210\u4e3a\u957f\u671f\u70ed\u95e8\u7684\u8bdd\u9898\u4e4b\u4e00\u3002\u5728\u65e5\u5e38\u996e\u98df\u4e4b\u5916\uff0c\u6d88\u8d39\u8005\u4eec\u4f3c\u4e4e\u5bf9\u4e8e\u80fd\u591f\u5feb\u901f\u5730\u3001\u6709\u9488\u5bf9\u6027\u5730\u76ca\u4e8e\u808c\u8089\u589e\u957f\u7684\u81b3\u98df\u8865\u5145\u5242\u5bc4\u4e88\u7740\u7279\u522b\u7684\u671f\u671b\u3002\u8fd9\u4e5f\u662f\u4e3a\u4ec0\u4e48\u8d8a\u6765\u8d8a\u591a\u66fe\u7ecf\u53ea\u5728\u8de8\u56fd\u516c\u53f8\u7684\u533b\u5b66\u8425\u517b\u54c1\u914d\u65b9\u4e0a\u624d\u80fd\u4e00\u7779\u82b3\u540d\u7684\u8425\u517b\u7d20\u5f00\u59cb\u8d70\u5165\u666e\u901a\u6d88\u8d39\u8005\u7684\u89c6\u91ce\uff0c\u4f5c\u4e3a\u72ec\u7acb\u7684\u8425\u517b\u8865\u5145\u5242\u6216\u666e\u901a\u98df\u54c1\u7684\u914d\u6599\u5728\u5e02\u9762\u4e0a\u5f00\u59cb\u6d41\u884c\u8d77\u6765\u3002<\/span><\/p>\n<\/blockquote>\n

HMB \u662f\u4ec0\u4e48\uff1f<\/span><\/strong><\/span><\/p>\n

\n

\u03b2-\u7f9f\u57fa-\u03b2-\u7532\u57fa\u4e01\u9178\uff0c\u6587\u4e2d\u7b80\u79f0HMB\uff08\u03b2-Hydroxy \u03b2-Methylbutyrate\uff09\uff0c \u662f\u4eba\u4f53\u5fc5\u9700\u6c28\u57fa\u9178\u201c\u4eae\u6c28\u9178\uff08leucine\uff09\u201d\u7684\u4ee3\u8c22\u4ea7\u7269\u4e4b\u4e00\u3002\u4e00\u4e2a70\u516c\u65a4\u7684\u6210\u5e74\u7537\u5b50\u6bcf\u5929\u4f1a\u751f\u4ea70.2-0.4\u514b\u7684HMB [1]\u3002\u5982\u56fe1\u6240\u793a\uff0cHMB\u5728\u86cb\u767d\u8d28\u7684\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u627f\u62c5\u7740\u8bb8\u591a\u4e0d\u540c\u7684\u89d2\u8272[2], \u4f46\u6700\u88ab\u4eba\u719f\u77e5\u7684\u529f\u6548\u662f\u5176\u52a9\u86cb\u767d\u5408\u6210\u548c\u6297\u5206\u89e3\u4ee3\u8c22\u7684\u6027\u8d28\u3002<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u56fe1. HMB\u8865\u5145\u5242\u53ef\u80fd\u7684\u6709\u5229\u4e8e\u9aa8\u9abc\u808c\u7684\u4f5c\u7528\u673a\u5236[2]<\/sup><\/span><\/p>\n<\/blockquote>\n

\u8865\u5145HMB\u4e0e\u4eae\u6c28\u9178\u7684\u5dee\u522b\u662f\u4ec0\u4e48\uff1fHMB\u6f5c\u5728\u4f18\u52bf\u5728\u54ea\uff1f<\/strong><\/span><\/span><\/p>\n

\n

\"\"<\/p>\n

\u56fe2. HMB\u7684\u751f\u6210\u548c\u4ee3\u8c22\u673a\u5236[2]<\/sup><\/span><\/p>\n

KIC: alpha\u2010ketoisocaproic acid; HB: beta\u2010hydroxybutyrate; HMG-CoA: 3-hydroxy-3-methyl-glutaryl-CoA.\u00a0<\/span>\u2460 BCAA aminotransferase; <\/span>\u2461BCKA dehydrogenase; <\/span>\u2462KIC dioxygenase; <\/span>\u2463glutamine synthetase; <\/span>\u2464alanine aminotransferase<\/span><\/p>\n

\u4ece\u56fe2\u4e2d\u53ef\u4ee5\u770b\u5230\uff0c\u4eba\u4f53\u5728\u4eae\u6c28\u9178\u7684\u81ea\u7136\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u4f1a\u4ea7\u751fHMB\u3002\u5927\u591a\u6570HMB\u7684\u4e34\u5e8a\u7814\u7a76\u4f7f\u7528\u7684\u90fd\u662f\u6bcf\u65e53\u514b\u5de6\u53f3\u7684\u5242\u91cf\uff08\u4e0b\u4e00\u7bc7\u6587\u7ae0\u201cHMB\u5728\u8fd0\u52a8\uff0c\u75be\u75c5\u548c\u8870\u8001\u65b9\u9762\u7684\u4e34\u5e8a\u7814\u7a76\u4e0e\u5c55\u671b<\/a>\u201d\u4f1a\u6709\u8be6\u7ec6\u4ecb\u7ecd\uff09\uff0c\u800c\u6444\u51653\u514b\u7684HMB\u76f8\u5f53\u4e8e\u6444\u516560\u514b\u7684\u4eae\u6c28\u9178\u3002\u90a3\u4e48\uff0c\u4e3a\u4ec0\u4e48\u6211\u4eec\u4e0d\u76f4\u63a5\u8865\u5145\u5927\u91cf\u4eae\u6c28\u9178\u5e76\u8ba9\u8eab\u4f53\u53bb\u81ea\u7136\u751f\u6210HMB\uff0c\u800c\u662f\u9009\u62e9\u76f4\u63a5\u8865\u5145HMB\u5462\uff1f\u5728\u4eba\u4f53\u5185\uff0c\u5927\u5242\u91cf\u7684\u4eae\u6c28\u9178\u8865\u7ed9\u4f1a\u52a0\u5267\u652f\u94fe\u03b1-\u916e\u9178\u8131\u6c22\u9176\uff08branched-chain alpha-keto acid dehydrogenase, BCKD\uff09\u7684\u6d3b\u52a8\u3002\u56e0\u6b64\uff0c \u4f5c\u4e3aBCKD\u7684\u5e95\u7269\uff0c\u53e6\u5916\u4e24\u79cd\u652f\u94fe\u6c28\u57fa\u9178 \uff08branched-chain amino acid\uff09\uff1a\u7f2c\u6c28\u9178\uff08valine\uff09\u4e0e\u5f02\u4eae\u6c28\u9178\uff08isoleucine\uff09\u7684\u6c27\u5316\u53cd\u5e94\u4e5f\u4f1a\u76f8\u5e94\u589e\u52a0\uff0c\u6700\u7ec8\u9020\u6210\u4f53\u6db2\u4e2d\u7f2c\u6c28\u9178\u4e0e\u5f02\u4eae\u6c28\u9178\u7684\u6d41\u5931\u3002 \u6240\u4ee5\uff0c\u5f53\u6444\u5165\u5927\u91cf\u4eae\u6c28\u9178\u65f6\uff0c \u540e\u7eed\u4ea7\u751f\u7684\u8fde\u9501\u53cd\u5e94\u4f1a\u5bfc\u81f4\u652f\u94fe\u6c28\u57fa\u9178\u7684\u6d53\u5ea6\u5931\u8861\uff0c\u4ece\u800c\u5bf9\u4eba\u4f53\u7ec4\u7ec7\u4e2d\u7684\u86cb\u767d\u8d28\u65b0\u9648\u4ee3\u8c22\u9020\u6210\u4e0d\u826f\u5f71\u54cd[2]<\/sup>\u3002
\u4e0e\u6b64\u540c\u65f6\uff0c\u4eba\u4f53\u6bcf\u5929\u81ea\u8eab\u5408\u6210\u7684HMB\u91cf\u8f83\u6709\u9650\u3001\u8840\u6d46\u4e2dHMB\u7684\u534a\u8870\u671f\u8f83\u77ed\uff08\u534a\u8870\u671f\u5728\u8840\u6d46\u4e2d\u7ea6\u4e3a2.5\u5c0f\u65f6\u5de6\u53f3\uff0c\u901a\u8fc7\u80be\u810f\u6392\u51fa\uff09\uff0c\u4f46\u53e3\u670dHMB\u8865\u5145\u5242\u670970%-85%\u90fd\u80fd\u4fdd\u7559\u5728\u4f53\u5185\u5e76\u52a0\u4ee5\u5229\u7528[3]<\/sup>\u3002\u9274\u4e8e\u56fe 1\u4e2d\u6240\u8ff0\u7684HMB\u4e0e\u808c\u8089\u4ee3\u8c22\u7684\u76f4\u63a5\u53cd\u5e94\u673a\u5236\uff0c\u76f4\u63a5\u8865\u5145HMB\u4f3c\u4e4e\u662f\u4e00\u4e2a\u66f4\u76f4\u63a5\uff0c\u66f4\u9ad8\u6548\u7684\u9009\u62e9\u3002<\/span><\/p>\n<\/blockquote>\n

HMB\u6bd2\u6027\u6216\u526f\u4f5c\u7528<\/span><\/strong><\/span><\/p>\n

\n

\u5927\u91cf\u8865\u5145HMB\u662f\u5426\u5177\u6709\u6bd2\u6027\u6216\u4f1a\u5e26\u6765\u4e0d\u826f\u526f\u4f5c\u7528\u5462\uff1f\u9996\u5148\uff0cHMB\u672c\u8eab\u5c31\u662f\u4eba\u4f53\u4ee3\u8c22\u4ea7\u7269\u4e4b\u4e00\u3002 \u5176\u6b21\uff0c\u76ee\u524d\u7684\u7814\u7a76\u5e76\u6ca1\u6709\u53d1\u73b0HMB\u5728\u5065\u5eb7\u4eba\u7fa4\u4e2d\u6709\u8010\u53d7\u6027\u548c\u6bd2\u6027\u65b9\u9762\u7684\u95ee\u9898[2]\u3002\u4f46\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6211\u4eec\u7684\u8eab\u4f53\u662f\u4e00\u4e2a\u7cbe\u5bc6\u800c\u590d\u6742\u7684\u7cfb\u7edf\uff0c\u6bcf\u65f6\u6bcf\u523b\u90fd\u5728\u8fdb\u884c\u5408\u6210\u4e0e\u5206\u89e3\uff0c\u6240\u4ee5\u4e8c\u8005\u76f8\u5bf9\u5e73\u8861\u7684\u72b6\u6001\u5bf9\u4e8e\u800c\u5065\u5eb7\u7684\u8eab\u4f53\u800c\u8a00\u5fc5\u4e0d\u53ef\u5c11\u3002 \u5c3d\u7ba1\u6211\u4eec\u628a\u5927\u90e8\u5206\u7cbe\u529b\u653e\u5728\u4fc3\u8fdb\u5408\u6210\u4e0a\uff0c \u4f46\u6291\u5236\u5206\u89e3\u4ee3\u8c22\u9020\u6210\u7684\u6f5c\u5728\u5f71\u54cd\u4e5f\u4e0d\u5bb9\u5ffd\u89c6\u3002\u4f8b\u5982\uff0c\u8c37\u6c28\u9170\u80fa\uff08glutamine\uff09\u6709\u52a9\u4e8e\u7ef4\u6301\u80a0\u7c98\u819c\u5b8c\u6574\u6027\u548c\u514d\u75ab\u7ec6\u80de\u7684\u6b63\u5e38\u529f\u80fd\uff0c\u5728\u86cb\u767d\u6c34\u89e3\u8fc7\u7a0b\u4e2d\u4ece\u808c\u8089\u91ca\u653e\u8fdb\u5165\u8840\u6db2\u3002\u7406\u8bba\u4e0a\u6765\u8bf4\uff0c\u9274\u4e8eHMB\u5177\u6709\u589e\u8fdb\u5408\u6210\u4ee3\u8c22\u3001\u6291\u5236\u5206\u89e3\u4ee3\u8c22\u7684\u6027\u8d28\uff0c\u8fc7\u591a\u7684\u5206\u89e3\u6291\u5236\u53ef\u80fd\u4f1a\u9020\u6210\u8c37\u6c28\u9170\u80fa\u7684\u77ed\u7f3a\uff0c\u4f7f\u5185\u810f\u7ec4\u7ec7\u53ef\u63a5\u6536\u7684\u8c37\u6c28\u9170\u80fa\u53d7\u9650\u3002\u4e5f\u6709\u5b9e\u9a8c\u66fe\u63d0\u5230\u5bf9\u4e8e\u81ea\u8eab\u8c37\u6c28\u9170\u80fa\u672c\u6765\u5c31\u504f\u4f4e\u7684\u4eba\u7fa4\uff08\u6bd4\u5982\u5371\u91cd\u75c5\u4eba\uff09\u6765\u8bf4\uff0c \u6444\u53d6HMB\u4f1a\u8fdb\u4e00\u6b65\u964d\u4f4e\u8fd9\u9879\u6307\u6807\u3002\u7531\u6b64\u53ef\u4ee5\u8054\u60f3\u5230\uff0cHMB\u5728\u5e2e\u52a9\u6076\u75c5\u8d28\u75c5\u4eba\u589e\u52a0\u808c\u8089\u7684\u540c\u65f6\u662f\u5426\u4f1a\u51cf\u5c11\u8c37\u6c28\u9170\u80fa\u6216\u5728\u5176\u4ed6\u5185\u810f\u5668\u5b98\u4e0a\u4ea7\u751f\u526f\u4f5c\u7528\u5462[2]\uff1f\u8865\u5145HMB\u7684\u540c\u65f6\u662f\u5426\u9700\u8981\u8865\u5145\u989d\u5916\u7684\u8c37\u6c28\u9170\u80fa\uff1f\u8fd9\u4e2a\u95ee\u9898\u5c1a\u672a\u5b9a\u8bba\uff0c\u4e1a\u5185\u4e5f\u9700\u8981\u66f4\u591a\u5bc6\u5207\u7684\u5173\u6ce8\u548c\u76f8\u5173\u5b9e\u9a8c\u6765\u9610\u660e\u76f8\u5173\u673a\u5236\u3002<\/span><\/p>\n<\/blockquote>\n

\u5728\u7b80\u5355\u4e86\u89e3\u4e86HMB\u7684\u4ee3\u8c22\u3001\u4f5c\u7528\u673a\u5236\u548c\u5b89\u5168\u6027\u4e4b\u540e\uff0c\u628aHMB\u843d\u5b9e\u5230\u5177\u4f53\u6cbb\u7597\u5e72\u9884\u65b9\u6848\u4e2d\u7684\u529f\u6548\u53c8\u4f1a\u662f\u4ec0\u4e48\u6837\u7684\u5462\uff1f\u4e0b\u4e00\u7bc7\u6587\u7ae0\u5c06\u4f1a\u56f4\u7ed5HMB\u5728\u8fd0\u52a8\uff0c\u75be\u75c5\uff0c\u548c\u8870\u8001<\/a>\u4e09\u4e2a\u65b9\u9762\u7ee7\u7eed\u5c55\u5f00\u8ba8\u8bba\u3002<\/span><\/p>\n

\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/p>\n

\n

[1] Nissen, S., Sharp, R., Ray, M., Rathmacher, J. A., Rice, D., Fuller Jr, J. C., … & Abumrad, N. (1996). Effect of leucine metabolite \u03b2-hydroxy-\u03b2-methylbutyrate on muscle metabolism during resistance-exercise training. Journal of Applied Physiology, 81(5), 2095-2104.
[2] Hole\u010dek, M. (2017). Beta\u2010hydroxy\u2010beta\u2010methylbutyrate supplementation and skeletal muscle in healthy and muscle\u2010wasting conditions. Journal of cachexia, sarcopenia and muscle, 8(4), 529-541.
[3] Vukovich, M. D., Slater, G., Macchi, M. B., Turner, M. J., Fallon, K., Boston, T., & Rathmacher, J. (2001). \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. The Journal of nutritional biochemistry, 12(11), 631-639.<\/span><\/p>\n<\/blockquote>\n

\u672c\u6587\u4f5c\u8005<\/strong><\/span><\/span><\/p>\n

\n

\u4e07 \u6797 \u7f8e\u56fd\u6ce8\u518c\u8425\u517b\u5e08
\u8425\u517b\u5b66\u7855\u58eb\uff0c\u6bd5\u4e1a\u4e8e\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u6559\u5e08\u5b66\u9662\u3002
\u73b0\u4efb\u804c\u4e8e\u6cd5\u56fd\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66\u96c6\u56e2\uff0c\u4ece\u4e8b\u8425\u517b\u4e34\u5e8a\u7814\u7a76\u3002\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66\u96c6\u56e2\u81f4\u529b\u4e8e\u4e3a\u98df\u54c1\u548c\u8425\u517b\u54c1\u884c\u4e1a\u63d0\u4f9b\u5168\u65b9\u4f4d\u7684\u670d\u52a1\u6765\u4fdd\u62a4\u5168\u7403\u6d88\u8d39\u8005\u7684\u5065\u5eb7\u3002<\/span><\/p>\n<\/blockquote>","protected":false},"excerpt":{"rendered":"

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