{"id":2207,"date":"2019-06-13T11:08:25","date_gmt":"2019-06-13T03:08:25","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2207"},"modified":"2023-04-20T12:53:32","modified_gmt":"2023-04-20T04:53:32","slug":"hmb-sports-disease-senility","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2207","title":{"rendered":"HMB\u4e0e\u8fd0\u52a8\uff0c\u75be\u75c5\u548c\u8870\u8001\u65b9\u9762\u7684\u4e34\u5e8a\u7814\u7a76\u4e0e\u5c55\u671b"},"content":{"rendered":"
HMB\u4f5c\u7528\u673a\u5236<\/a>, <\/span>\u4e34\u5e8a\u7814\u7a76<\/a>, <\/span>\u6885\u91cc\u57c3\u68c0\u6d4b<\/a>, <\/span>\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66<\/a>, <\/span>\u7f8e\u56fd\u6ce8\u518c\u8425\u517b\u5e08<\/a><\/div>\n\n

\u4e0a\u4e00\u7bc7\u6587\u7ae0\u63d0\u5230\uff0c\u03b2-\u7f9f\u57fa-\u03b2-\u7532\u57fa\u4e01\u9178\uff0c\u5373HMB\uff08\u03b2-Hydroxy \u03b2-Methylbutyrate\uff09\u5728\u4f53\u5185\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u62c5\u4efb\u4e86\u8bb8\u591a\u4e0d\u540c\u7684\u89d2\u8272<\/a>\uff08\u5982\u56fe1\u6240\u793a\uff09\uff0c\u5e76\u5177\u6709\u5e2e\u52a9\u86cb\u767d\u5408\u6210\u53ca\u6291\u5236\u86cb\u767d\u6c34\u89e3\u7684\u6027\u8d28[1]<\/sup>\u3002\u8fd9\u4e00\u7bc7\u6587\u7ae0\u5c06\u66f4\u52a0\u8be6\u7ec6\u7684\u5c55\u5f00\u5bf9HMB\u5728\u8fd0\u52a8\uff0c\u75be\u75c5\uff0c\u548c\u8870\u8001\u65b9\u9762\u529f\u6548\u7684\u63a2\u8ba8\u3002<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u56fe1. HMB\u8865\u5145\u5242\u53ef\u80fd\u7684\u6709\u5229\u4e8e\u9aa8\u9abc\u808c\u7684\u4f5c\u7528\u673a\u5236[1]<\/sup><\/span><\/p>\n

\u56fd\u9645\u8fd0\u52a8\u8425\u517b\u5b66\u4f1a\u7acb\u573a<\/strong><\/span><\/span><\/p>\n

\n

\u57fa\u4e8e\u5bf9HMB\u4f5c\u4e3a\u8425\u517b\u8865\u5145\u5242\u7684\u6587\u732e\u8fdb\u884c\u6279\u5224\u6027\u5206\u6790\u540e\uff0c\u56fd\u9645\u8fd0\u52a8\u8425\u517b\u5b66\u4f1a\uff08International Society of Sports Nutrition\uff09\u53d1\u5e03\u5173\u4e8eHMB\u7684\u7acb\u573a\u58f0\u660e[2]<\/sup>\uff0c\u73b0\u603b\u7ed3\u5982\u4e0b:
1. HMB\u7684\u4f5c\u7528\u673a\u5236\u5305\u62ec\u6291\u5236\u86cb\u767d\u6c34\u89e3\u548c\u589e\u52a0\u86cb\u767d\u8d28\u5408\u6210\u3002
2. \u76ee\u524d\u6709\u4e24\u79cd\u5f62\u5f0f\u7684HMB\uff1aHMB\u9499\u76d0\uff08HMB-Ca\uff09\u548c\u6e38\u79bb\u9178\u5f62\u5f0f\u7684HMB\uff08HMB-FA\uff09\u3002\u4e0eHMB-Ca\u76f8\u6bd4\uff0cHMB-FA\u53ef\u4ee5\u66f4\u5927\u7a0b\u5ea6\u5730\u589e\u52a0HMB\u5728\u8840\u6d46\u4e2d\u7684\u5438\u6536\u548c\u4fdd\u7559\u3002\u7136\u800c\uff0c\u5bf9HMB-FA\u7684\u7814\u7a76\u4ecd\u5904\u4e8e\u8d77\u6b65\u9636\u6bb5\uff0c\u5e76\u6ca1\u6709\u8db3\u591f\u7684\u7814\u7a76\u8bc1\u636e\u6765\u8bc4\u4f30\u8fd9\u4e24\u79cd\u5f62\u5f0f\u529f\u6548\u7684\u4f18\u52a3\u3002
3. \u4e13\u4e1a\u8fd0\u52a8\u5458\u6216\u4e1a\u4f59\u7231\u597d\u8005\u670d\u7528HMB\u53ef\u51cf\u5c11\u7531\u8fd0\u52a8\u8bf1\u53d1\u7684\u9aa8\u9abc\u808c\u635f\u4f24\uff0c\u4ece\u800c\u589e\u5f3a\u6062\u590d\u6548\u679c\u3002
4. HMB\u6548\u679c\u4e0e\u670d\u7528\u7684\u65f6\u95f4\u8282\u70b9\u6709\u5173,\u4e34\u8fd1\u8bad\u7ec3\u524d\u670d\u7528HMB\u80fd\u8ba9\u4e13\u4e1a\u8fd0\u52a8\u5458\u53d7\u76ca\u3002
5. HMB-FA\u5728\u8fd0\u52a8\u524d0.5-1\u5c0f\u65f6\u4f7f\u7528\u6700\u4e3a\u6709\u6548\uff0c\u800cHMB-Ca\u5728\u8fd0\u52a8\u524d1-2\u5c0f\u65f6\u670d\u7528\u53ef\u53d1\u6325\u6700\u4f73\u6548\u679c\u3002
6. \u5728\u8fdb\u884c\u9002\u5f53\u7684\u953b\u70bc\u7684\u524d\u63d0\u4e0b\uff0c\u6bcf\u5929\u670d\u752838\u6beb\u514b\/\u6bcf\u5343\u514b\u4f53\u91cd\u7684HMB\u53ef\u589e\u5f3a\u4e13\u4e1a\u8fd0\u52a8\u5458\u6216\u4e1a\u4f59\u7231\u597d\u8005\u7684\u9aa8\u9abc\u808c\u8010\u529b\u548c\u7206\u53d1\u529b\u3002
7. \u5c31\u957f\u671f\u6536\u76ca\u800c\u8a00\uff0c\u4e00\u822c\u8ba4\u4e3a\u5728\u8fdb\u884c\u4e00\u573a\u9ad8\u5f3a\u5ea6\u8fd0\u52a8\/\u6bd4\u8d5b\u524d\uff0c\u4ee53\u514b\/\u5929\u7684\u5242\u91cf\uff0c\u8fde\u7eed\u670d\u7528\u81f3\u5c112\u5468\u65b9\u53ef\u53d6\u5f97\u6700\u7406\u60f3\u6548\u679c\u3002
8. \u6444\u5165HMB\u4e0e\u7ed3\u6784\u5316\u953b\u70bc\u8ba1\u5212\u76f8\u7ed3\u5408\u53ef\u80fd\u51cf\u5c11\u66f4\u591a\u8102\u80aa\u91cf\u3002
9. \u5b9e\u9a8c\u5df2\u7ecf\u8bc1\u660eHMB\u53ef\u4ee5\u589e\u52a0\u8001\u5e74\u4eba\u548c\u4e45\u5750\u4e0d\u52a8\u7684\u4eba\u7fa4\u7684\u7626\u4f53\u91cd\u548c\u673a\u4f53\u529f\u80fd\u3002
10. \u76ee\u524d\u7684\u8bc1\u636e\u663e\u793a\u957f\u671f\u670d\u7528HMB\u5bf9\u4e8e\u5e74\u8f7b\u4eba\u7fa4\u548c\u8001\u5e74\u4eba\u7fa4\u90fd\u662f\u5b89\u5168\u7684\u3002<\/span><\/p>\n<\/blockquote>\n

\u8fd0\u52a8\u5458\u53ca\u8fd0\u52a8\u8868\u73b0<\/strong><\/span><\/span><\/p>\n

\n

\u5bf9\u4e8e\u8fd0\u52a8\u5458\u6765\u8bf4\uff0cHMB\u5e2e\u52a9\u808c\u8089\u751f\u957f\u53ca\u4fee\u590d\u8fd0\u52a8\u53d7\u635f\u808c\u8089\u7684\u529f\u6548[3]<\/sup>\u4e5f\u5728\u5f88\u65e9\u4e4b\u524d\u5c31\u5f97\u5230\u4e86\u5173\u6ce8\u3002\u5728\u8fd9\u4e00\u4eba\u7fa4\u4e2d\uff0cHMB\u7684\u4f5c\u7528\u673a\u5236\u4e3b\u8981\u662f\u56f4\u7ed5\u5728\u5176\u5728mTOR (mechanistic target of rapamycin) pathway\u4e2d\u63d0\u9ad8\u86cb\u767d\u5408\u6210\u7684\u4f5c\u7528[4]<\/sup>\u3002\u5f88\u591a\u9488\u5bf9\u8fd0\u52a8\u5458\u4eba\u7fa4\u5f00\u5c55\u7684HMB\u8bd5\u9a8c\u90fd\u63d0\u5230\u4e86HMB\u80fd\u589e\u52a0\u7626\u4f53\u91cd\uff0c\u964d\u4f4e\u4f53\u8102\uff0c\u52a0\u5f3a\u808c\u8089\u529b\u91cf\uff0c\u4f46\u5173\u4e8eHMB\u662f\u5426\u80fd\u63d0\u9ad8\u6709\u6c27\u8fd0\u52a8\u8868\u73b0\uff08\u6444\u6c27\u91cf\uff0c\u6362\u6c14\u9600\u503c\uff0c\u6700\u5927\u8d1f\u8377\u5fc3\u7387\u7b49\uff09\u6307\u6807\u548c\u65e0\u6c27\u8fd0\u52a8\u7684\u8868\u73b0\u7ed3\u8bba\u5374\u5e76\u4e0d\u7edf\u4e00[5][6][7][8]<\/sup>\u3002\u5bf9\u4e8e\u4e4b\u524d\u672a\u53d7\u8fc7\u4e13\u4e1a\u8bad\u7ec3\u7684\u53d7\u8bd5\u8005\u6765\u8bf4\uff0c\u4e00\u65e6\u5f00\u59cb\u8bad\u7ec3\uff0cHMB\u8865\u5145\u5242\u4f3c\u4e4e\u6709\u589e\u52a0\u808c\u8089\u6570\u91cf\u548c\u8d28\u91cf\uff0c\u589e\u52a0\u7626\u4f53\u91cd\u65b9\u9762\uff0c\u548c\u51cf\u5c11\u808c\u8089\u635f\u4f24\u7684\u6548\u679c[9][10]<\/sup>\u3002\u5c3d\u7ba1\u56fd\u9645\u8425\u517b\u5b66\u4f1a\u7684\u7acb\u573a\u58f0\u660e\u4e2d\u4e5f\u63d0\u5230HMB\u5bf9\u4e1a\u4f59\u7231\u597d\u8005\u6bd4\u4e13\u4e1a\u8fd0\u52a8\u5458\u66f4\u6709\u6548\u679c\uff0c\u4f46\u5177\u4f53\u7684\u539f\u56e0\u548c\u673a\u5236\u5374\u5c1a\u672a\u77e5\u6653\u3002<\/span><\/p>\n<\/blockquote>\n

\u5371\u91cd\u75c5\u4eba<\/strong><\/span><\/span><\/p>\n

\n

\u4e0e\u8fd0\u52a8\u5458\u4e0d\u540c\uff0c\u5bf9\u4e8e\u5371\u91cd\u75c5\u4eba\u6765\u8bf4\uff0cHMB\u7684\u4f5c\u7528\u673a\u5236\u4e3b\u8981\u805a\u7126\u4e8e\u901a\u8fc7\u5411\u4e0b\u8c03\u8282\u6cdb\u7d20 – \u86cb\u767d\u9176\u4f53\u7cfb\u7edf\uff08ubiquitin-proteasome\uff09\u6d3b\u52a8\u4e2d\u7684\u5173\u952e\u6027\u63a7\u5236\u6210\u5206\u4ee5\u51cf\u5c11\u86cb\u767d\u6c34\u89e3\uff0c\u4ece\u800c\u51cf\u5c11\u7626\u4f53\u91cd\u7684\u6d41\u5931[11]<\/sup>\u3002\u751a\u81f3\u6709\u8bd5\u9a8c\u63d0\u53caHMB\u5728\u6297\u708e\u75c7\uff0c\u63d0\u9ad8\u514d\u75ab\u529b\u53ca\u6539\u5584\u764c\u75c7\u7ec6\u80de\u751f\u957f\u65b9\u9762\u7684\u5f71\u54cd[12][13][14]<\/sup>\u3002\u76ee\u524d\u5df2\u7ecf\u6709\u7814\u7a76\u7740\u773c\u4e8e\u5c06HMB\u4f5c\u4e3a\u5355\u72ec\u7684\u8865\u5145\u5242\u6216\u4e0e\u4f20\u7edf\u8425\u517b\u8865\u5145\u5242\u76f8\u7ed3\u5408\uff0c\u770b\u5176\u662f\u5426\u80fd\u8868\u73b0\u51fa\u540c\u7b49\u6216\u8005\u66f4\u5353\u8d8a\u7684\u529f\u6548\u3002\u5f53\u4f5c\u4e3a\u5355\u72ec\u8865\u5145\u5242\u65f6\uff0c\u4ee53\u514b\/\u5929\u7684\u5242\u91cf\uff0c\u8fde\u7eed\u4e00\u5468\u7684\u5e72\u9884\uff0cHMB\u5728\u91cd\u75c7\u75c5\u623f\u7684\u6162\u6027\u963b\u585e\u6027\u80ba\u75c5\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u4e86\u6297\u708e\u75c7\u7684\u6548\u679c\u3002\u75c5\u4eba\u7684\u767d\u7ec6\u80de\uff0cC\u53cd\u5e94\u86cb\u767d\uff0c\u53ca\u808c\u6c28\u9178\u9150\u964d\u4f4e\uff0c\u80c6\u56fa\u9187\u548c\u603b\u86cb\u767d\u6570\u91cf\u63d0\u9ad8\uff0c\u5e76\u4e14\u6709\u8d85\u8fc7\u534a\u6570\u7684\u5b9e\u9a8c\u7ec4\u75c5\u60a3\u7684\u80ba\u529f\u80fd\uff08\u5bf9\u7167\u7ec4\u4ec5\u6709\u56db\u5206\u4e4b\u4e00\u7684\u60a3\u8005\uff09\u5f97\u5230\u63d0\u5347[12]<\/sup>\u3002<\/span>
\u4e00\u9879\u5305\u542b100\u4f4d\u5371\u91cd\u521b\u4f24\u75c5\u4eba\u7684\u4e09\u81c2\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u8005\u5bf9\u6bd4\u4e86\u4e09\u79cd\u540c\u7b49\u80fd\u91cf\u548c\u6c2e\u91cf\u7684\u8425\u517b\u8865\u5145\u5242\uff1a\u5355\u72ecHMB\u8865\u5145\u5242\uff083g HMB\uff09\u3001HMB\u590d\u5408\u8425\u517b\u8865\u5145\u5242\uff083g HMB + 14g\u7cbe\u6c28\u9178arginine + 14g\u8c37\u6c28\u9170glutamine: HMB\/ARG\/GLN\uff09\u3001\u548c\u5b89\u6170\u5242\u5728\u5371\u91cd\u521b\u4f24\u75c5\u4eba\u7684\u6c2e\u5e73\u8861\uff08\u8861\u91cf\u4eba\u4f53\u86cb\u767d\u8d28\u4ee3\u8c22\u8d8b\u52bf\u7684\u6307\u6807\uff09\u65b9\u9762\u7684\u7597\u6548\u3002 \u7ecf\u8fc728\u5929\u7684\u8bd5\u9a8c\u540e\uff0cHMB\u7ec4\u65e0\u8bba\u662f\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff08p=0.05\uff09\u8fd8\u662f\u5728\u4e0eHMB\/ARG\/GLN\u76f8\u6bd4\uff08p<0.02\uff09\uff0c\u5728\u6c2e\u5e73\u8861\u7684\u6539\u5584\u65b9\u9762\u90fd\u8868\u73b0\u51fa\u6cbb\u7597\u4f18\u52bf[15]<\/sup>\u3002\u4e0e\u8fd9\u4e2a\u7814\u7a76\u7684\u7ed3\u679c\u4e0d\u540c\uff0c\u540c\u6837\u7684\u590d\u5408\u8865\u5145\u5242\u5728\u56db\u671f\u764c\u75c7\u75c5\u4eba\u8eab\u4e0a\u7684\u4f53\u73b0\u51fa\u66f4\u597d\u7684\u4fdd\u5b58\u53bb\u8102\u7ec4\u7ec7\u4f53\u91cd\uff08Fat-free mass\uff09\u7684\u529f\u6548[13]<\/sup>\u3002\u540c\u6837\u7684\uff0cHMB\/ARG\/GLN\u7684\u590d\u5408\u8425\u517b\u8865\u5145\u5242\u5728\u643a\u5e26HIV\u7684\u75c5\u4eba\u8eab\u4e0a\u4e5f\u4f53\u73b0\u51fa\u6539\u5584\u7626\u4f53\u91cd\u5e76\u52a0\u5f3a\u514d\u75ab\u6307\u6807\uff08CD3\u3001CD8\u548cHIV\u75c5\u6bd2\u91cf\uff09\u7b49\u6548\u679c[14]<\/sup>\u3002\u4e5f\u6709\u5728\u5c0f\u9f20\u8eab\u4e0a\u7684\u7814\u7a76\u6307\u51fa\uff0c\u5f53\u643a\u5e26\u764c\u75c7\u5c0f\u9f20\u6444\u53d6\u5927\u4e8e\u6bcf\u5343\u514b\u4f53\u91cd0.125\u514b\u7684HMB\u65f6\uff0c\u4f53\u91cd\u964d\u4f4e\u7684\u901f\u5ea6\u660e\u663e\u653e\u7f13\u3002\u5728\u8fd9\u4e00\u5b9e\u9a8c\u4e2d\uff0c\u65e0\u8bba\u662f\u5355\u65b9\u9762\u8865\u51450.25g\/kg HMB\uff0c \u8fd8\u662f\u5355\u65b9\u9762\u8865\u51450.6g\/kg EPA\uff08\u53e6\u4e00\u516c\u8ba4\u7684\u6291\u5236\u808c\u8089\u6d41\u5931\u7684\u8425\u517b\u7d20)\uff0c\u6291\u6216\u662f\u5c06\u4e24\u8005\u76f8\u7ed3\u5408\uff0c\u643a\u5e26\u764c\u75c7\u7684\u5c0f\u9f20\u90fd\u8868\u73b0\u51fa\u6297\u6076\u75c5\u8d28\uff08\u589e\u52a0\u808c\u8089\u5408\u6210\uff0c\u51cf\u5c11\u808c\u8089\u5206\u89e3\uff09\u7684\u6548\u679c\uff0c\u5176\u4e2dHMB\u4e0eEPA\u7ed3\u5408\u7684\u5e72\u9884\u63aa\u65bd\u6548\u679c\u6700\u660e\u663e[16]<\/sup>\u3002 \u5c3d\u7ba1HMB\u5728\u4eba\u7c7b\u4e0e\u8bd5\u9a8c\u5c0f\u9f20\u7684\u4f5c\u7528\u673a\u5236\u4e0a\u5fc5\u7136\u4f1a\u5b58\u5728\u5dee\u5f02\uff0c \u800cHMB\u5177\u4f53\u5982\u4f55\u5728\u4eba\u4f53\u4e2d\u6297\u6076\u75c5\u8d28\u7684\u5177\u4f53\u673a\u5236\u8fd8\u9700\u8981\u66f4\u591a\u7814\u7a76\u6765\u8bc1\u5b9e\uff0c\u4f46\u7ed3\u5408\u4e0d\u540c\u7684\u7814\u7a76\u53ef\u4ee5\u770b\u51fa\uff0cHMB\u5728\u4f18\u5316\u5371\u91cd\u75c5\u4eba\u53ca\u9ad8\u808c\u8089\u6d41\u5931\u98ce\u9669\u7684\u75c5\u4eba\u7684\u6cbb\u7597\u65b9\u6848\u4e2d\u5b58\u5728\u4e00\u5b9a\u6f5c\u529b\u3002<\/span><\/p>\n<\/blockquote>\n

\u8001\u9f84\u4eba\u53e3<\/strong><\/span><\/span><\/p>\n

\n

\u5c11\u808c\u75c7 (sarcopenia) \u6216\u662f\u7626\u4f53\u91cd\u7684\u6d41\u5931\u662f\u5065\u5eb7\u8870\u8001\u8fc7\u7a0b\u4e00\u4e2a\u5e38\u89c1\u7684\u96be\u9898\uff0c\u800cHMB\u4fc3\u8fdb\u7ec6\u80de\u4fee\u590d\u548c\u808c\u8089\u5408\u6210\u53ca\u6291\u5236\u86cb\u767d\u6c34\u89e3\u7b49\u7279\u6027\u4e5f\u5728\u8fd9\u4e00\u4eba\u7fa4\u7684\u9700\u6c42\u4e2d\u627e\u5230\u7528\u6b66\u4e4b\u5730\u3002 \u968f\u7740\u8001\u9f84\u4eba\u53e3\u7684\u4eba\u6570\u65e5\u76ca\u589e\u52a0\uff0c\u76ee\u524d\u7814\u7a76\u4e5f\u5f00\u59cb\u56f4\u7ed5\u7740HMB\u5bf9\u8001\u9f84\u4eba\u7fa4\u7684\u529f\u6548\u5c55\u5f00\u63a2\u7d22\u3002<\/span>
\u5bf9\u4e8e65\u5c81\u4ee5\u4e0a\u7684\u8001\u5e74\u4eba\uff0c\u5728\u6ca1\u6709\u6297\u963b\u529b\u8bad\u7ec3\u7684\u60c5\u51b5\u4e0b\uff0c\u6709\u5b9e\u9a8c\u63d0\u5230\u8fde\u7eed24\u5468\u6bcf\u65e53\u514b\u7684HMB\u8865\u5145\u5242\u53ef\u63d0\u9ad8\u6574\u4f53\u53ca\u817f\u90e8\u7626\u4f53\u91cd\u3001\u817f\u90e8\u5c48\u4f38\u80fd\u529b\u6216\u808c\u8089\u8d28\u91cf\u7b49\u6307\u6807\u3002\u5728\u52a0\u5165\u4e8624\u5468\u6297\u963b\u529b\u8bad\u7ec3\u540e, HMB\u9664\u4e86\u63d0\u9ad8\u4e0a\u8ff0\u6307\u6807\u7684\uff0c\u5728\u4f53\u8102\u80aa\uff0c\u63e1\u529b\u548c\u201c\u5750\u8d77-\u524d\u8fdb\u201d\u7b49\u6d4b\u8bd5\u4e2d\u4e5f\u6bd4\u670d\u7528HMB\u524d\u6709\u663e\u8457\u6539\u5584\u3002\u4f46\u5b9e\u9a8c\u7ec4\u548c\u5bf9\u7167\u7ec4\u4e4b\u95f4\u5e76\u65e0\u660e\u663e\u6cbb\u7597\u6548\u679c\uff08treatment effect\uff09\u533a\u522b[17]<\/sup>\u3002\u53e6\u4e00\u9879\u4e3a\u671f8\u5468\uff0c\u572865\u5c81\u4ee5\u4e0a\u8001\u5e74\u5973\u6027\u4e2d\u8fdb\u884c\u7684\u5b9e\u9a8c\u4e5f\u52a0\u5165\u4e86\u4e2d\u7b49\u5f3a\u5ea6\u7684\u953b\u70bc\u5e72\u9884\uff0c\u5e76\u4e14\u540c\u6837\u53d1\u73b0HMB\u80fd\u63d0\u9ad8\u7c7b\u4f3c\u7684\u8fd0\u52a8\u6307\u6807\uff08\u63e1\u529b\u53ca\u4e00\u9879\u4e0b\u8eaf\u4f53\u808c\u8089\u80fd\u529b\u6307\u6807-Short Physical Performance Battery\u9664\u5916\uff09[18]<\/sup>\u3002\u5f53\u628aHMB\u4e0e\u7cbe\u6c28\u9178\uff08arginine\uff09\u548c\u8d56\u6c28\u9178\uff08lysine\uff09\u540c\u65f6\u8865\u5145\u65f6\uff0c\u7626\u4f53\u91cd\u3001\u86cb\u767d\u8d28\u8f6c\u6362\u3001\u8fd0\u52a8\u673a\u80fd\u6307\u6807\u53ca\u4f53\u8102\u7387\u7b49\u65b9\u9762\u4e5f\u4f1a\u6709\u663e\u8457\u6539\u5584[19][20]<\/sup>\u3002\u5c3d\u7ba1\u5b9e\u9a8c\u7ed3\u8bba\u663e\u793aHMB\u5728\u63d0\u9ad8\u8001\u5e74\u4eba\u7fa4\u7684\u808c\u8089\u8d28\u91cf\u65b9\u9762\u4f3c\u4e4e\u6709\u4e00\u5b9a\u529f\u6548\uff0c\u4f46\u6297\u963b\u529b\u8fd0\u52a8\u5728\u63d0\u9ad8\u808c\u8089\u8d28\u91cf\u7b49\u6307\u6807\u4e2d\u4f3c\u4e4e\u627f\u62c5\u66f4\u52a0\u91cd\u8981\u7684\u89d2\u8272[18]\uff0c\u800cHMB\u4e0e\u5176\u4ed6\u6c28\u57fa\u9178\u7684\u590d\u5408\u8865\u5145\u5242\u529f\u6548\u4f3c\u4e4e\u4e5f\u5e26\u7740\u201c\u53cc\u4fdd\u9669\u201d\u7684\u5149\u73af\u3002<\/span>
\u5982\u679c\u8001\u5e74\u4eba\u5904\u4e8e\u957f\u671f\u5367\u5e8a\u3001\u65e0\u6cd5\u8fd0\u52a8\u7684\u72b6\u6001\uff0cHMB\u5bf9\u4e8e\u4fdd\u5b58\u808c\u8089\u662f\u5426\u4f9d\u7136\u6709\u6548\u5462\uff1f\u5728\u4e00\u9879\u5e73\u884c\u5bf9\u7167\u7814\u7a76\u4e2d\uff0c\u5367\u5e8a\u4e14\u63a5\u53d7\u7ba1\u9972\u7684\u7597\u517b\u9662\u8001\u4eba\u6bcf\u5929\u6444\u5165\u542b\u67092g HMB\u7684\u80a0\u5185\u8425\u517b\u5236\u5242\uff0c\u6301\u7eed14-28\u5929\u540e\uff0c\u5b9e\u9a8c\u7ec4\u548c\u5bf9\u7167\u7ec4\u7684\u4f53\u91cd\u4e0eBMI\u53d8\u5316\u65e0\u660e\u663e\u5dee\u5f02\u3002\u5b9e\u9a8c\u7ec4\u8840\u6db2\u5c3f\u7d20\u6c2e\uff08BUN\uff09\u548c\u5c3f\u6db2\u5c3f\u7d20\u6c2e\uff08UUN\uff09\u6709\u660e\u663e\u964d\u4f4e\uff0c\u4f46\u5bf9\u7167\u7ec4\u7684BUN\u65e0\u660e\u663e\u53d8\u5316\uff0cUUN\u5b58\u5728\u660e\u663e\u589e\u52a0\u8d8b\u52bf\uff0c\u4e24\u4e2a\u7ec4\u522b\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u6cbb\u7597\u5dee\u5f02\u3002\u7531\u751f\u7269\u6307\u6807\u53ef\u89c1\uff0c\u8865\u5145HMB\u5bf9\u4e8e\u9632\u6b62\u5367\u5e8a\u4e14\u63a5\u53d7\u80a0\u5185\u8425\u517b\u7684\u8001\u5e74\u4eba\u8fd9\u4e00\u9ad8\u5371\u4eba\u7fa4\u5177\u6709\u4e00\u5b9a\u9632\u6b62\u808c\u8089\u6d41\u5931\u7684\u6548\u679c[21]<\/sup>\u3002<\/span><\/p>\n<\/blockquote>\n

\u5c0f\u7ed3\u4e0e\u5c55\u671b<\/strong><\/span><\/span><\/p>\n

\n

\u5c31\u50cf\u4e00\u679a\u786c\u5e01\u7684\u6b63\u53cd\u4e24\u9762\uff0cHMB\u4fc3\u8fdb\u808c\u8089\u5408\u6210\u548c\u6291\u5236\u86cb\u767d\u6c34\u89e3\u7684\u6027\u8d28\u6b63\u5728\u88ab\u4eba\u4eec\u52a0\u4ee5\u7814\u7a76\uff0c\u5e76\u5229\u7528\u5230\u63d0\u9ad8\u8fd0\u52a8\u5458\u8868\u73b0\uff0c\u9632\u6b62\u5371\u91cd\u75c5\u4eba\u7626\u4f53\u91cd\u6d41\u5931\uff0c\u53ca\u4f18\u5316\u8001\u9f84\u7fa4\u4f53\u7684\u673a\u4f53\u529f\u80fd\u7b49\u65b9\u9762\u3002\u5c3d\u7ba1\u9664\u4e86\u56fd\u9645\u8fd0\u52a8\u8425\u517b\u5b66\u4f1a\u7684\u7acb\u573a\u58f0\u660e\u5916\uff0c\u5173\u4e8eHMB\u7684\u5177\u4f53\u529f\u6548\u4ecd\u672a\u6709\u7edf\u4e00\u5b9a\u8bba\uff0c\u4f46\u4ece\u76ee\u524d\u7684\u7814\u7a76\u770b\u6765\uff0cHMB\u4e0d\u4ec5\u53ef\u4ee5\u4f5c\u4e3a\u76ee\u524d\u516c\u8ba4\u6cbb\u7597\u65b9\u6848\u7684\u4e00\u9879\u652f\u6301\u6027\u5e72\u9884\u63aa\u65bd\uff0c\u4e5f\u53ef\u5f53\u4f5c\u4e00\u4e2a\u72ec\u7acb\u65b9\u6848\u88ab\u4e0d\u540c\u9700\u6c42\u7684\u4eba\u7fa4\u7eb3\u5165\u8003\u91cf\u3002\u4ece\u53e6\u4e00\u65b9\u9762\u6765\u770b\uff0c\u5e74\u9f84\u3001\u8fd0\u52a8\u60c5\u51b5\u3001\u5e72\u9884\u65b9\u5f0f\u7b49\u8bf8\u591a\u53d8\u91cf\u5bf9HMB\u7684\u6548\u679c\u90fd\u4f1a\u5b58\u5728\u5f71\u54cd\u3002\u5728\u672a\u6765\uff0c\u9664\u4e86\u5f00\u5c55\u66f4\u591a\u7814\u7a76\u9610\u660e\u4f5c\u7528\u673a\u5236\u5916\uff0c\u65e0\u8bba\u662f\u5b66\u672f\u754c\u8fd8\u662f\u4ea7\u4e1a\u754c\u90fd\u9700\u7ed3\u5408\u7cbe\u51c6\u8425\u517b\u7684\u53d1\u5c55\u8d8b\u52bf\uff0c\u9488\u5bf9\u4e0d\u540c\u4eba\u7fa4\u7684\u9700\u6c42\u63a2\u7d22\u4e2a\u6027\u5316\u7684\u5e94\u7528\u65b9\u6848\u3002\u5c4a\u65f6\uff0c\u66f4\u591a\u4eba\u7fa4\u4e0e\u4ea7\u4e1a\u5c06\u4f1a\u5f97\u76ca\u4e8eHMB\u5e26\u6765\u7684\u6f5c\u5728\u79ef\u6781\u6548\u5e94\u3002<\/span><\/p>\n<\/blockquote>\n

\u53c2\u8003\u6587\u732e<\/span><\/strong><\/span><\/p>\n

\n

[1] Hole\u010dek, M. (2017). Beta\u2010hydroxy\u2010beta\u2010methylbutyrate supplementation and skeletal muscle in healthy and muscle\u2010wasting conditions. Journal of cachexia, sarcopenia and muscle, 8(4), 529-541.
[2] Wilson, J. M., Fitschen, P. J., Campbell, B., Wilson, G. J., Zanchi, N., Taylor, L., … & Ziegenfuss, T. N. (2013). International society of sports nutrition position stand: beta-hydroxy-beta-methylbutyrate (HMB). Journal of the International Society of Sports Nutrition, 10(1), 6.
[3] Knitter, A. E., Panton, L., Rathmacher, J. A., Petersen, A., & Sharp, R. (2000). Effects of \u03b2-hydroxy-\u03b2-methylbutyrate on muscle damage after a prolonged run. Journal of Applied Physiology, 89(4), 1340-1344.
[4] Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., … & Rathmacher, J. A. (2018). Impact of the calcium form of \u03b2-hydroxy-\u03b2-methylbutyrate upon human skeletal muscle protein metabolism. Clinical nutrition, 37(6), 2068-2075.
[5] Durkalec-Michalski, K., & Jeszka, J. (2015). The efficacy of a \u03b2-hydroxy-\u03b2-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study. Journal of the International Society of Sports Nutrition, 12(1), 31.
[6] Durkalec-Michalski, K., & Jeszka, J. (2016). The effect of \u03b2-hydroxy-\u03b2-methylbutyrate on aerobic capacity and body composition in trained athletes. Journal of strength and conditioning research, 30(9), 2617-2626.
[7] Durkalec-Michalski, K., Jeszka, J., & Podg\u00f3rski, T. (2017). The effect of a 12-week beta-hydroxy-beta-methylbutyrate (HMB) supplementation on highly-trained combat sports athletes: a randomised, double-blind, placebo-controlled crossover study. Nutrients, 9(7), 753.
[8] Portal, S., Zadik, Z., Rabinowitz, J., Pilz-Burstein, R., Adler-Portal, D., Meckel, Y., … & Nemet, D. (2011). The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study. European journal of applied physiology, 111(9), 2261-2269.
[9] Panton, L. B., Rathmacher, J. A., Baier, S., & Nissen, S. (2000). Nutritional supplementation of the leucine metabolite \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) during resistance training. Nutrition, 16(9), 734-739.
[10] Van Someren, K. A., Edwards, A. J., & Howatson, G. (2005). Supplementation with \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) and \u03b1-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. International journal of sport nutrition and exercise metabolism, 15(4), 413-424.
[11] Smith, H. J., Wyke, S. M., & Tisdale, M. J. (2004). Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by \u03b2-hydroxy-\u03b2-methylbutyrate. Cancer research, 64(23), 8731-8735.
[12]Hsieh, L., Chien, S., Huang, M., Tseng, H., & Chang, C. (2006). Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pacific journal of clinical nutrition, 15(4), 544.
[13] May, P. E., Barber, A., T D\u2019Olimpio, J., Hourihane, A., & Abumrad, N. N. (2002). Reversal of cancer-related wasting using oral supplementation with a combination of \u03b2-hydroxy-\u03b2-methylbutyrate, arginine, and glutamine. The American journal of surgery, 183(4), 471-479.
[14] Clark, R. H., Feleke, G., Din, M., Yasmin, T., Singh, G., Khan, F. A., & Rathmacher, J. A. (2000). Nutritional Treatment for Acquired Immunodeficiency Virus\u2010Associated Wasting Using \u03b2\u2010Hydroxy \u03b2\u2010Methylbutyrate, Glutamine, and Arginine: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Study. Journal of Parenteral and Enteral Nutrition, 24(3), 133-139.
[15] Kuhls, Deborah A., John A. Rathmacher, M. Diana Musngi, Donald A. Frisch, Jeremiah Nielson, Annabel Barber, Allan D. MacIntyre, Jay E. Coates, and John J. Fildes. “\u03b2-Hydroxy-\u03b2-methylbutyrate supplementation in critically ill trauma patients.” Journal of Trauma and Acute Care Surgery 62, no. 1 (2007): 125-132.
[16] Smith, H. J., Mukerji, P., & Tisdale, M. J. (2005). Attenuation of proteasome-induced proteolysis in skeletal muscle by \u03b2-hydroxy-\u03b2-methylbutyrate in cancer-induced muscle loss. Cancer research, 65(1), 277-283.
[17] Stout, J. R., Smith-Ryan, A. E., Fukuda, D. H., Kendall, K. L., Moon, J. R., Hoffman, J. R., … & Mustad, V. A. (2013). Effect of calcium \u03b2-hydroxy-\u03b2-methylbutyrate (CaHMB) with and without resistance training in men and women 65+ yrs: a randomized, double-blind pilot trial. Experimental gerontology, 48(11), 1303-1310.
[18] Berton, L., Bano, G., Carraro, S., Veronese, N., Pizzato, S., Bolzetta, F., … & Coin, A. (2015). Effect of oral beta-hydroxy-beta-methylbutyrate (HMB) supplementation on physical performance in healthy old women over 65 years: an open label randomized controlled trial. PLoS One, 10(11), e0141757.
[19] Baier, S., Johannsen, D., Abumrad, N., Rathmacher, J. A., Nissen, S., & Flakoll, P. (2009). Year\u2010long Changes in Protein Metabolism in Elderly Men and Women Supplemented With a Nutrition Cocktail of \u03b2\u2010Hydroxy\u2010\u03b2\u2010methylbutyrate (HMB), L\u2010Arginine, and L\u2010Lysine. Journal of Parenteral and Enteral Nutrition, 33(1), 71-82.
[20] Flakoll, P., Sharp, R., Baier, S., Levenhagen, D., Carr, C., & Nissen, S. (2004). Effect of \u03b2-hydroxy-\u03b2-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition, 20(5), 445-451.<\/span>
[21] Hsieh, L. C., Chow, C. J., Chang, W. C., Liu, T. H., & Chang, C. K. (2010). Effect of \u03b2-hydroxy-\u03b2-methylbutyrate on protein metabolism in bed-ridden elderly receiving tube feeding. Asia Pacific journal of clinical nutrition, 19(2), 200-208.<\/span><\/p>\n<\/blockquote>\n

\u672c\u6587\u4f5c\u8005<\/strong><\/span><\/span><\/p>\n

\n

\u4e07 \u6797 \u7f8e\u56fd\u6ce8\u518c\u8425\u517b\u5e08
\u8425\u517b\u5b66\u7855\u58eb\uff0c\u6bd5\u4e1a\u4e8e\u7f8e\u56fd\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u6559\u5e08\u5b66\u9662\u3002
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