{"id":2473,"date":"2020-03-19T13:27:55","date_gmt":"2020-03-19T05:27:55","guid":{"rendered":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2473"},"modified":"2023-04-18T14:05:11","modified_gmt":"2023-04-18T06:05:11","slug":"fecal-microbiota-profile-at-diagnosis-in-the-french-imodi-cohort-of-breast-cancer-2","status":"publish","type":"post","link":"https:\/\/www.merieuxnutrisciences.com.cn\/?p=2473","title":{"rendered":"\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66\u5b8c\u6210\u4e73\u817a\u764c\u60a3\u8005\u80a0\u9053\u83cc\u7fa4\u5206\u6790\u7684\u961f\u5217\u7814\u7a76"},"content":{"rendered":"<div class=\"taxonomy-post_tag wp-block-post-terms\"><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E4%B8%B4%E5%BA%8A%E6%B5%8B%E8%AF%95\" rel=\"tag\">\u4e34\u5e8a\u6d4b\u8bd5<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E4%B8%B4%E5%BA%8A%E7%A0%94%E7%A9%B6\" rel=\"tag\">\u4e34\u5e8a\u7814\u7a76<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E4%B9%B3%E8%85%BA%E7%99%8C%E5%8F%91%E7%97%85%E7%8E%87\" rel=\"tag\">\u4e73\u817a\u764c\u53d1\u75c5\u7387<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E6%A2%85%E9%87%8C%E5%9F%83%E6%A3%80%E6%B5%8B\" rel=\"tag\">\u6885\u91cc\u57c3\u68c0\u6d4b<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E6%A2%85%E9%87%8C%E5%9F%83%E8%90%A5%E5%85%BB%E7%A7%91%E5%AD%A6\" rel=\"tag\">\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66<\/a><span class=\"wp-block-post-terms__separator\">, <\/span><a href=\"https:\/\/www.merieuxnutrisciences.com.cn\/?tag=%E8%82%A0%E9%81%93%E8%8F%8C%E7%BE%A4%E5%88%86%E6%9E%90\" rel=\"tag\">\u80a0\u9053\u83cc\u7fa4\u5206\u6790<\/a><\/div>\n\n<p><span style=\"font-size: 14px;\">\u4e73\u817a\u764c\u662f\u5973\u6027\u6700\u5e38\u89c1\u7684\u764c\u75c7\u3002\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\uff0c\u4e73\u817a\u764c\u53d1\u75c5\u7387\u5728\u53d1\u8fbe\u56fd\u5bb6\u548c\u53d1\u5c55\u4e2d\u56fd\u5bb6\u5747\u5448\u4e0a\u5347\u8d8b\u52bf\u3002\u79d1\u5b66\u5bb6\u6b63\u5728\u66f4\u5168\u9762\u5730\u7814\u7a76\u8fd9\u79cd\u75be\u75c5\uff0c\u4f46\u4ecd\u5b58\u5728\u5c1a\u672a\u5f97\u5230\u89e3\u7b54\u7684\u7591\u95ee\u3002\u5f97\u76ca\u4e8e\u5728\u5fae\u751f\u6001\u9886\u57df\u7684\u957f\u671f\u79ef\u7d2f\u548c\u4f18\u52bf\uff0c\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66\u7684Biofortis\u4e34\u5e8a\u7814\u7a76\u4e2d\u5fc3\uff0c\u57fa\u4e8eIMODI\u5408\u4f5c\u5e73\u53f0\uff0c\u5728\u6cd5\u56fd\u91cc\u6602\u53ca\u7b2c\u620e\u7684\u4e24\u5bb6\u533b\u9662\u62db\u52df\u4e86\u5171112\u540d\u5973\u6027\u4e73\u817a\u764c\u60a3\u8005\uff0c\u4ee5\u89c2\u5bdf\u5c40\u90e8\u4e73\u817a\u764c\u60a3\u8005\u5728\u521d\u6b21\u786e\u8bca\u65f6\u7684\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u7ec4\u6210\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u6b64\u6b21\u7814\u7a76\u62db\u52df\u7684\u60a3\u8005\u961f\u5217\u7684\u5e74\u9f84\u4e2d\u4f4d\u6570\u4e3a53.5\u5c81[\u5e74\u9f84\u8303\u56f4\uff1a27-78]\uff0c\u670959%\u7684\u60a3\u8005\u5904\u4e8e\u66f4\u5e74\u671f\u3002\u5176\u4e2d\uff0c2\uff05\u60a3\u8005\u4f53\u91cd\u8fc7\u8f7b\uff08BMI &lt; 18.5kg \/m\u00b2\uff09\uff0c52\uff05\u4f53\u91cd\u6b63\u5e38\uff0818.5 \u2264 BMI \u2264 24.9\uff09\uff0c22\uff05\u8d85\u91cd\uff0825 \u2264 BMI \u2264 29.9\uff09\uff0c\u8fd8\u670924\uff05\u80a5\u80d6\uff08BMI \u2265 30\uff09\u3002\u4e73\u817a\u764c\u7684\u4e34\u5e8a\u5206\u671f\u5206\u5e03\u4e3a\uff1a3\uff050\u671f\u300110\uff05I\u671f\uff0c48\uff05IIA\u671f\uff0c21\uff05IIB\u671f\uff0c14\uff05IIIA\u671f\uff0c0\uff05IIIB\u671f\u548c3\uff05IIIC\u671f\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7814\u7a76\u4f7f\u7528MiSeq System\u5bf9\u7caa\u4fbf\u6837\u672c\u768416S rRNA V3-V4\u533a\u57df\u8fdb\u884c\u6d4b\u5e8f\uff0c\u5e76\u4f7f\u7528\u5185\u90e8\u751f\u7269\u4fe1\u606f\u7ba1\u9053\u5bf9\u7caa\u4fbf\u6837\u672c\u4e2d\u6240\u68c0\u6d4b\u5230\u7684\u83cc\u7fa4\u505a\u4e86\u95e8\u548c\u79d1\u7b49\u7ea7\u7684\u5206\u7c7b\u5b66\u5206\u7c7b\uff0c\u4e14\u7528\u5185\u90e8\u5206\u6790\u5e73\u53f0\u8ba1\u7b97\u76f8\u5bf9\u4e30\u5ea6\uff08relative abundances, \uff05\uff09\uff0c\u591a\u6837\u6027\uff08Shannon index\uff09\u548c\u4e30\u5bcc\u5ea6\uff08rarefied Chao index\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u7814\u7a76\u7ed3\u679c\u53d1\u73b0\uff0c\u83cc\u7fa4\u591a\u6837\u6027\u548c\u4e30\u5bcc\u5ea6\u4e4b\u95f4\u5b58\u5728\u663e\u8457\u7684\u6b63\u76f8\u5173\uff08r\u00b2= 0.661\uff1bp &lt;0.0001\uff09\u3002\u83cc\u7fa4\u591a\u6837\u6027\u548c\u4e30\u5bcc\u5ea6\u5747\u672a\u53d7\u4f53\u91cd\u6307\u6570\u6216\u7edd\u7ecf\u7684\u5f71\u54cd\uff0c\u4f46\u764c\u75c7\u665a\u671f\uff08IIIA\u671f\uff0cIIIB\u671f\uff0cIIIC\u671f\uff09\u76f8\u8f83\u4e8e\u764c\u75c7\u65e9\u671f\uff08I\u671f\uff0cIIA\u671f\uff0cIIB\u671f\uff09\u5728\u8fd9\u4e24\u9879\u6307\u6807\u4e0a\u6709\u6240\u589e\u52a0\uff0c\u4e14\u5728\u83cc\u7684\u5206\u5b50\u4e9a\u578b\u4e0a\u6709\u6240\u4e0d\u540c\u3002\u60a3\u8005\u83cc\u7fa4\u5728\u95e8\uff08phylum\uff09\u4e0a\u7684\u4e30\u5bcc\u7a0b\u5ea6\u76f8\u4f3c\uff0c\u5176\u4e2d\u4ee5\u62df\u6746\u83cc\u95e8\uff08Bacteroidetes\uff09\uff0838\uff05\uff09\u548c\u539a\u58c1\u83cc\u95e8\uff08Firmicutes\uff09\uff0852\uff05\uff09\u4e3a\u4e3b\u3002\u8f6f\u58c1\u83cc\u95e8\uff08Tenericutes\uff09\u548c\u53f6\u72b6\u83cc\u95e8\uff08phyltisphaerae\uff09\u5728\u4f53\u91cd\u6307\u6570\u8f83\u9ad8\u7684\u60a3\u8005\u4e2d\u66f4\u9ad8\uff08\u5206\u522b\u4e3ap = 0.060\u548cp = 0.091\uff09\u3002\u6b64\u5916\uff0c\u6b63\u5e38\u4eba\u7684\u771f\u6746\u83cc\u79d1\uff08Eubacteriaceae\uff09\u663e\u8457\u9ad8\u4e8e\u80a5\u80d6\u60a3\u8005\uff08p = 0.005\uff09\uff0c\u800c\u5047\u5355\u80de\u83cc\u79d1\uff08Pseudomonadaceae\uff09\u663e\u8457\u4f4e\u4e8e\u80a5\u80d6\u60a3\u8005\uff08p = 0.016\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u4e0e\u672a\u7edd\u7ecf\u60a3\u8005\u76f8\u6bd4\uff0c\u7edd\u7ecf\u60a3\u8005\u7684\u53d8\u5f62\u83cc\u95e8\uff08Proteobacteria phylum\uff09\u6c34\u5e73\u66f4\u9ad8\uff08p = 0.076\uff09\u3002\u6b64\u5916\uff0c\u7edd\u7ecf\u60a3\u8005\u7684\u5fae\u7403\u83cc\u76ee\uff08Micrococcaceae family\uff09\u5f80\u5f80\u8f83\u9ad8\uff08p = 0.060\uff09\u3002\u6839\u636e\u5206\u5b50\u4e9a\u578b\uff0c\u4e92\u517b\u83cc\u95e8\uff08Synergistetes\uff09\uff08p = 0.0533\uff09\u548c\u75a3\u5fae\u83cc\u95e8\uff08Verrucomicrobia\uff09\uff08p = 0.072\uff09\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\u60a3\u8005\u4e2d\u6bd4\u5728\u7ba1\u72b6A\u578b\u764c\u75c7\u60a3\u8005\u4e2d\u66f4\u9ad8\u3002\u5728IIB\u671f\u60a3\u8005\u4e2d\uff0c\u6c28\u57fa\u9178\u7403\u83cc\u79d1\uff08Acidaminococcaceae\uff09\uff08p = 0.020\uff09\u7684\u6bd4\u4f8b\u663e\u7740\u9ad8\u4e8eIIA\u671f\u60a3\u8005\u4e2d\u7684\u6bd4\u4f8b\u3002\u76f8\u53cd\uff0cIIB\u671f\u7684\u53bb\u6c1f\u7ef4\u9709\u83cc\u79d1\uff08Defluvitalaceae\uff09\uff08p = 0.012\uff09\uff0c\u80a0\u7403\u83cc\u79d1\uff08Enterococcaceae\uff09\uff08p = 0.045\uff09\u548c\u4e19\u9178\u687f\u83cc\u79d1\uff08Propionibacteriaceae\uff09\uff08p = 0.034\uff09\u660e\u663e\u4f4e\u4e8eIIA\u671f\u60a3\u8005\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">\u672c\u6b21\u4e73\u817a\u764c\u60a3\u8005\u961f\u5217\u4e2d\u663e\u793a\u4e86\u7caa\u4fbf\u5fae\u751f\u7269\u7fa4\u8c31\u4f1a\u968f\u67d0\u4e9b\u4e34\u5e8a\u53c2\u6570\u800c\u53d8\u5316\uff0c\u800c\u5fae\u751f\u7269\u83cc\u7fa4\u4e0e\u996e\u98df\u4e4b\u95f4\u7684\u6f5c\u5728\u76f8\u4e92\u4f5c\u7528\u53ca\u66f4\u591a\u7684\u7814\u7a76\u5206\u6790\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002\u5c3d\u7ba1\u672c\u6b21\u7814\u7a76\u7684\u6837\u672c\u91cf\u76f8\u5bf9\u8f83\u5c0f\uff0c\u4f46\u5176\u5bf9\u672a\u6765\u7684\u76f8\u5173\u5b9e\u9a8c\u8bbe\u8ba1\u53ef\u63d0\u4f9b\u542f\u793a\u6027\u53c2\u8003\u4f5c\u7528\u3002\u5728\u672a\u6765\uff0c\u6837\u672c\u91cf\u66f4\u5927\u7684\u7814\u7a76\u53ef\u4f7f\u6211\u4eec\u5bf9\u4e73\u817a\u764c\u60a3\u8005\u53ca\u5176\u83cc\u7fa4\u53c2\u6570\u6709\u66f4\u6df1\u5165\u7684\u7406\u89e3\u3002\u656c\u8bf7\u671f\u5f85\u540e\u7eed\u7684\u6210\u679c\u53d1\u8868\u3002<\/span><\/p>\n<p><span style=\"font-size: 14px;\">IMODI\uff08Innovative Models Initiative Against Cancer\uff09\uff0c\u4e3a\u5f00\u53d1\u764c\u75c7\u7684\u4e34\u5e8a\u524d\u671f\u9884\u6d4b\u6a21\u578b\u7684\u6cd5\u56fd\u8054\u76df\u7ec4\u7ec7\uff0c\u5176\u753118\u5bb6\u7814\u7a76\u673a\u6784\u3001\u5927\u5b66\u3001\u533b\u836f\u4f01\u4e1a\u548c\u751f\u7269\u79d1\u6280\u516c\u53f8\u7ec4\u6210\uff0c\u6210\u5458\u5305\u62ec\u6cd5\u56fd\u56fd\u5bb6\u5065\u5eb7\u4e0e\u533b\u5b66\u7814\u7a76\u9662\uff08Inserm\uff09\u3001\u6cd5\u56fd\u56fd\u5bb6\u79d1\u5b66\u7814\u7a76\u4e2d\u5fc3\uff08CNRS\uff09\u3001\u65af\u7279\u62c9\u65af\u5821\u5927\u5b66\u3001\u8d5b\u8bfa\u83f2\u3001Ispen\u3001\u6885\u91cc\u57c3\u8425\u517b\u79d1\u5b66\u7b49\u3002\u8be5\u8054\u76df\u65e8\u5728\u901a\u8fc7\u7814\u7a76\u4e0d\u540c\u764c\u75c7\u7684\u5728\u4eba\u4f53\u5185\u7684\u7279\u5f81\u4e0e\u7279\u6027\uff0c\u5e0c\u671b\u5728\u764c\u75c7\u5f62\u6210\u521d\u671f\u80fd\u5c3d\u65e9\u5730\u901a\u8fc7\u6709\u8c61\u5f81\u6027\u7684\u6307\u6807\u8fdb\u884c\u8bca\u65ad\uff0c\u4e14\u5bfb\u627e\u6700\u6709\u6548\u3001\u6700\u5177\u6709\u9488\u5bf9\u6027\u7684\u6297\u764c\u6cbb\u7597\u65b9\u6cd5\u3002\u5728\u5f00\u53d1\u6a21\u578b\u7684\u9636\u6bb5\uff0cIMODI\u7684\u4e3b\u8981\u7814\u7a76\u5185\u5bb9\u4e4b\u4e00\u4fbf\u662f\u6df1\u5165\u4e86\u89e3\u764c\u75c7\u60a3\u8005\u4f53\u5185\u7684\u5fae\u751f\u7269\u83cc\u7fa4\u3002<\/span><\/p>\n<p>\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>\u672c\u6b21\u4e73\u817a\u764c\u60a3\u8005\u961f\u5217\u4e2d\u663e\u793a\u4e86\u7caa\u4fbf\u5fae\u751f\u7269\u7fa4\u8c31\u4f1a\u968f\u67d0\u4e9b\u4e34\u5e8a\u53c2\u6570\u800c\u53d8\u5316\uff0c\u800c\u5fae\u751f\u7269\u83cc\u7fa4\u4e0e\u996e\u98df\u4e4b\u95f4\u7684\u6f5c\u5728\u76f8\u4e92\u4f5c\u7528\u53ca\u66f4\u591a\u7684\u7814\u7a76\u5206\u6790\u4ecd\u5728\u8fdb\u884c\u4e2d\u3002\u5c3d\u7ba1\u672c\u6b21\u7814\u7a76\u7684\u6837\u672c\u91cf\u76f8\u5bf9\u8f83\u5c0f\uff0c\u4f46\u5176\u5bf9\u672a\u6765\u7684\u76f8\u5173\u5b9e\u9a8c\u8bbe\u8ba1\u53ef\u63d0\u4f9b\u542f\u793a\u6027\u53c2\u8003\u4f5c\u7528\u3002\u5728\u672a\u6765\uff0c\u6837\u672c\u91cf\u66f4\u5927\u7684\u7814\u7a76\u53ef\u4f7f\u6211\u4eec\u5bf9\u4e73\u817a\u764c\u60a3\u8005\u53ca\u5176\u83cc\u7fa4\u53c2\u6570\u6709\u66f4\u6df1\u5165\u7684\u7406\u89e3\u3002\u656c\u8bf7\u671f\u5f85\u540e\u7eed\u7684\u6210\u679c\u53d1\u8868\u3002<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[120],"tags":[2628,803,3153,617,618,3152],"modified_by":"amyadmin","_links":{"self":[{"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/2473"}],"collection":[{"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2473"}],"version-history":[{"count":2,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/2473\/revisions"}],"predecessor-version":[{"id":14748,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=\/wp\/v2\/posts\/2473\/revisions\/14748"}],"wp:attachment":[{"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2473"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2473"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.merieuxnutrisciences.com.cn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2473"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}